Efficacy and tolerability of the new antiepileptic drugs II: Treatment of refractory epilepsy
نویسندگان
چکیده
Objective: To assess the evidence demonstrating efficacy, tolerability, and safety of seven new antiepileptic drugs (AEDs) (gabapentin, lamotrigine, topiramate, tiagabine, oxcarbazepine, levetiracetam, and zonisamide) in the treatment of children and adults with refractory partial and generalized epilepsies. Methods: A 23-member committee including general neurologists, pediatric neurologists, epileptologists, and doctors in pharmacy evaluated the available evidence based on a structured literature review including MEDLINE, Current
منابع مشابه
مقایسهی سطح سرمی فنوباربیتال و فنیتوئین بین کودکان مبتلا به صرع پایدار و صرع پایدار مقاوم
Background & objective: Due to high kinetic variation of antiepileptic medications in children, judgment on the efficacy of intravenous phenytoin and phenobarbital in treatment of refractory status epilepsy, requires measurement of serum levels of the drugs. The aim of this study was determine and compare serum levels of phenytoin and phenobarbital, as the two major and common first- line drugs...
متن کاملEfficacy and tolerability of the new antiepileptic drugs, II: Treatment of refractory epilepsy: report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy Society.
PURPOSE To assess the evidence demonstrating efficacy, tolerability, and safety of seven new antiepileptic drugs (AEDs) [gabapentin (GBP), lamotrigine (LTG), topiramate (TPM), tiagabine (TGB), oxcarbazepine (OXC), levetiracetam (LEV), and zonisamide (ZNS)] in the treatment of children and adults with refractory partial and generalized epilepsies. METHODS A 23-member committee, including gener...
متن کاملChallenges in the Treatment of Epilepsy
Epilepsy is one of the most important diseases of nervous system that involves 0.5-1% of the population. In spite of new developments in antiepileptic drugs, between 20-30% of epileptic patients can not be controlled and even those who are controlled with antiepileptic drugs suffer from their adverse events. Epileptic patients have different challenges in relation to the disease and its medicat...
متن کاملEfficacy and tolerability of the new antiepileptic drugs I: Treatment of new onset epilepsy
Objective: To assess the evidence demonstrating efficacy, tolerability, and safety of seven new antiepileptic drugs (AEDs) (gabapentin, lamotrigine, topiramate, tiagabine, oxcarbazepine, levetiracetam, and zonisamide—reviewed in the order in which these agents received approval by the US Food and Drug Administration) in the treatment of children and adults with newly diagnosed partial and gener...
متن کاملEfficacy and tolerability of the first antiepileptic drug in children with newly diagnosed idiopathic epilepsy
PURPOSE Limited data are available for the effectiveness of the antiepileptic drugs in children in daily clinical practice. The aim of this study was to investigate the efficacy and tolerability of the first prescribed old and new antiepileptic drugs in children with newly diagnosed idiopathic epilepsy during a 12-month period. METHOD A total of 289 children (141 females and 148 males) who re...
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